Novel social distancing detector using local binary pattern in comparison with principal component analysis to improve accuracy

The objective is to detect Novel Social Distancing using Local Binary Pattern (LBP) in comparison with Principal Component Analysis (PCA). Social Distance deduction is performed using Local Binary Pattern(N=20) and Principal Component Analysis(N=20) algorithms. Google AI open Images dataset is used for image detection. Dataset contains more than 10,000 images. Accuracy of Principal Component Analysis is 89.8% and Local Binary Pattern is 93.9%. There exists a statistical significant difference between LBP and PCA with (p<0.05). Local Binary Pattern appears to perform significantly better than Principal Component Analysis for Social Distancing Detection. © 2023 Author(s).

Citrus sinensis (Sweet Oranges) Wastes: The Orange Wealth

The sweet oranges or Citrus sinensis (CS) fruit is a member of the family Rutaceae. It accounts for nearly 70% of the total annual production of the Citrus species. It is usually introduced in folk medicine to treat the common cold due to its high content of vitamin C that supports the immune system. The CS residues from orange juice industry are the peel and seeds that constitute about 50% of the juice industry wastes. Nevertheless, almost all the parts of the oranges can be consumed for industrial and medicinal uses. Citrus Sinensis peel (CSP) contains many nutrients and antinutrients. Nutrients in the aqueous and ethanol CSP extracts included carbohydrates, proteins, fixed oils, sugars, and amino acids. The antinutrients included saponins and tannins. Studies have documented the antioxidant properties of the CSP extract due to the phytochemical constituents, including flavonoids and phenolic compounds. These phytochemical properties encourage the usage of the CSP extract in the food industry and for medical purposes. The industrial uses of the CSP extracts involve food preservation due to their antimicrobial and antioxidant activities. The edible and industrial applications of the seed oil are among the documented uses of CS. The orange pomace powder has been found to increase the acceptability and the nutritional value of the cake when added in a percentage of 10% to the refined wheat. The residue of the CS has been identified as food supplements due to its high fiber and phenolics content. Moreover, the CS wastes are an excellent source for the production of biofuel and biodiesel. The wastes of CS represent an environmental burden. Hence, incorporating the CS residues in eco-friendly medical and industrial uses is of multiple benefits to the environment, the industry, and human health. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.

The graphic novel as a didactic resource in times of pandemic: an intercultural proposal to dynamise the course of Conversation of the Degree in Spanish Philology of the P. R. China

The pandemic scourge has marked a relentless turning point in the educational scene. Specifically, in the People's Republic of China, the context in which the present experience is set, online teaching has become the norm for a significant number of Spanish-speaking teachers without the option of returning. This situation, in addition to making the teaching of an eminently communicative subject such as Conversation difficult, raises the urgent need to redefine the teaching process by embracing proposals which, on the one hand, are in line with the identity of the target students and, on the other, stimulate active participation in the virtual classroom. This article contextualises and describes the proposal developed among second-year students of the Degree in Hispanic Philology through a proposal structured around two main axes: graphic novels and the ComicLife3 application.

Stratification of Risks of Tuberculosis Relapses during the Pandemic of the Novel Coronavirus Infection

The objective: to assess risk factors for tuberculosis relapse during the COVID-19 pandemic. Results. During the retrospective study, medical documents of patients treated for tuberculosis in 2020-2022 were analyzed. 140 patients above 18 years old with confirmed tuberculosis were included: newly diagnosed tuberculosis – 50 patients, early relapses – 50 patients, and late relapses – 40 patients. At the first stage, significant factors for relapse development were identified (ANOVA): diabetes (F=19402,8;p=0,000000), substances abuse (F=547,6;p=0,000000), alcohol abuse (F=149,7;p=0,000000), MDR MTB (F=107,8;p=0,000000), HIV infection (F=72,4;p=0,000000), imprisonment (F=49,5;p=0,000000), chronic respiratory diseases (F=47,1;p=0,000000), smoking (F=29,0;p=0,000000), and social status (F=28,9;p= 0,000000). At the second stage (cluster analysis), factors implementing the risks of development of early or late relapses were identified. As well as before the COVID-19 pandemic, social, medical and biological risk factors play a significant role in the development of tuberculosis relapses;history of COVID-19 was not one of the risk factors;and stratification of the risk factors made it possible to identify factors that contribute to development of both early and late relapses and to determine preventive measures. © 2023 New Terra Publishing House. All rights reserved.

The Wuhan Lockdown

The book's middle chapters examine the various bold and careful acts of Wuhan residents during the lockdown. A scrupulous student of China's internet, Yang devotes most of his attention to analyzing China's fast-changing internet culture through the lens of the Wuhan lockdown. After the Wuhan lockdown in early 2020, China imposed lockdown in every city where there was an outbreak, until it lifted the zero COVID policy in December 2022. [Extracted from the article] Copyright of Journal of Asian Studies is the property of Duke University Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)

Experience of Using Remdesivir in Patients with Novel Coronavirus Infection.

Timely, effective, and safe antiviral therapy in COVID-19 patients reduces complications, disability and mortality rates. The greatest concern with remdesivir is the risk of drug-induced liver injury, including in patients whose liver function is compromised by COVID-19. The aim of the study was to investigate the efficacy and safety of remdesivir in patients with confirmed SARSCoV-2 infection who had been admitted to an infectious diseases hospital in the Volgograd region in March 2022. Material(s) and Method(s): the authors carried out an open, non-randomised, single-arm study using medical records of 234 patients who had been diagnosed with "U07.1 COVID-19, virus identified" and prescribed remdesivir upon admission. The effectiveness of therapy was evaluated using two criteria: the need for oxygen supplementation or ventilatory support, or mortality. The authors conducted the evaluation on days 7, 14, and 28 using the six-point ordinal severity scale by Y. Wang et al. The safety of therapy was assessed on the basis of complaints and changes in laboratory findings. Result(s): for the patients prescribed remdesivir at admission, the 7-day mortality rate was 3.0%, the 14-day mortality rate was 5.6%, and the 28-day mortality rate was 7.3%. With the exception of a patient with myocardial infarction, all the patients who had been hospitalised with mild COVID-19 and prescribed remdesivir did not require oxygen therapy and/or transfer to intensive care and were discharged following recovery. The patients with moderate to severe COVID-19 had the 14-day mortality rate of 6.4% and the 28-day mortality rate of 8.6%. 17 patients (7.2%) discontinued remdesivir prematurely for various reasons, including adverse drug reactions. Remdesivir therapy of 5-10 days was associated with an increase in ALT activity by 2.7 +/- 0.8 times in 15.9% of patients with mild COVID-19, by 3.8 +/- 1.8 times in 20.4% of patients with moderately severe COVID-19, and by 4.8 +/- 2.7 times in 24% (12/50) of patients with severe COVID-19. In two patients (0.9%), the increase exceeded 10-fold the upper limit of normal. Conclusion(s): the obtained results support recommending remdesivir to patients with mild, moderate and severe COVID-19, including those with moderately elevated baseline activity of hepatic transaminases.Copyright © NEICON ISP LLC. All rights reserved.

Survey Regarding Changing Food Habits in Wake of COVID-19

The COVID-19 pandemic was caused by the emergence of the new coronavirus (SARS-Cov2) in Wuhan, China, on December 12, 2019, and it has significantly impacted human health. It has also caused abrupt changes in lifestyle that have had social and economic repercussions, including social exclusion and isolation at home. This study aimed to investigate how COVID-19 has affected the food habits and lifestyle of the general population. A cross-sectional survey was conducted in Chennai to assess the awareness level of the population regarding the protective measures they take during the pandemic, and 500 participants of all ages were included in the study. Statistical analysis was performed using SPSS software. The study found that over 50% of the participants increased their intake of vegetables and fruits, and about 49.33% decreased their intake of fast food and snacks. Furthermore, more than 40% of the participants added immune-boosting ingredients to their diet. These results suggest that the study population adopted healthier dietary habits and behaviors, including a more nutritious diet with more vegetables, immune-boosting foods, and increased water intake. © 2023 IEEE.

Clinical features of epilepsy course during COVID-19.

Background. Currently, a great body of data regarding the link between epilepsy and novel coronavirus infection (NCI) has been accumulated. Numerous studies have paid a great attention to rise in frequency and severity of epileptic seizures as well as failure of remission in individuals suffering from epilepsy. Objective(s): to study clinical and mental changes during NCI in patients with epilepsy. Material and methods. Fifty patients with epilepsy were examined, who were divided into two groups depending on the NCI history: Group 1 (main) - 25 patients undergone COVID-19 in the period from 2020 to 2022;Group 2 (control) - 25 patients not undergone COVID-19 during the same period. Slinical-anamnestic and psychometric methods were used as well as the following scales and questionnaires: National Hospital Seizure Severity Scale (NHS-3), Mini-Mental State Examination (MMSE), Hospital Anxiety and Depression Scale (HADS), Beck Depression Inventory (BDI), Medical Outcomes Study Sleep Scale (MOS-SS), Multidimensional Fatigue Inventory (MFI-20). Results. In patients with epilepsy who had undergone COVID-19, there was a tendency for more frequent epileptic seizures and increased severity of seizure course. Among such patients, mild depression and more severe asthenia, cognitive impairment, moderate sleep disturbances were more common than in the control group. Conclusion. The NCI pandemic has had a pronounced negative impact on the severity of epilepsy (the underlying disease).Copyright © 2023 IRBIS LLC. All Rights Reserved.

SARS-CoV-2 Vaccine Against Virus: Mission Accomplished!?

Since the beginning of the COVID-19 pandemic in late 2019, SARS-CoV-2 has started to optimize itself. After crossing the species barrier between bats and humans, it has developed mutations in the viral spike protein, in particular at positions 69/70, 452, 501, 614, and 681, that enhance binding to the ACE-2 receptor and entry into host cells, thereby promoting viral transmissibility and pathogenesis. Mutations at positions 417 and 484 have begun to undermine the effectiveness of convalescent plasma, monoclonal antibodies, and currently available vaccines. The targeted and convergent evolution of SARS-CoV-2, which occurred despite the proofreading activity of the exonuclease, has resulted so far in five variants of concern, which have replaced previous strains. This calls for a worldwide surveillance of viral evolution including animal transmission and the development of vaccines responding to escape variants and inducing mucosal immunity. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.

Clinical features of patients with severe acute respiratory syndrome coronavirus 2 Delta variant infection and abnormal liver function in Guangdong Province, China. TT -? ? ? ? ? ?.

Objective To investigate the clinical features of patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant infection and abnormal liver function in Guangdong Province, China. Methods The patients with SARS-CoV-2 Delta variant infection who belonged to the same chain of transmission in Guangdong Province (Guangzhou and Foshan) and were admitted to Guangzhou Eighth People's Hospital, Guangzhou Medical University from May 21 to June 18, 2021 were enrolled in this study, and the judgment criteria for liver function were alanine aminotransferase (male/female) > 50/40 U/L, aspartate aminotransferase > 40 U/L, total bilirubin > 26 mumol/L, gamma-glutamyl transpeptidase > 60 U/L, and alkaline phosphatase (ALK) > 125 U/L. Abnormality in any one item of the above criteria was defined as abnormal liver function, and such patients were included in analysis (the patients, aged < 18 years, who had a mild or moderate increase in ALP alone were not included in analysis). Clinical data were compared between the patients with normal liver function and those with abnormal liver function, and the etiology and prognosis of abnormal liver function were analyzed. The Mann-Whitney U test was used for comparison of continuous data between two groups;the chi-square test was used for comparison of categorical data between two groups. Results Among the 166 patients with SARS-CoV-2 Delta variant infection, 32 (19.3%) had abnormal liver function with mild-to-moderate increases in liver function parameters, and compared with the normal liver function group, the abnormal liver function group had a significantly higher proportion of critical patients (chi2=38.689, P < 0.001) and significantly higher age and inflammatory cytokines [C-reactive protein type, serum amyloid A, and interleukin-6 (IL-6)](all P < 0.05). Among the 32 patients with abnormal liver function, 13 patients had abnormal liver function on admission (defined as primary group), while 19 patients had normal liver function on admission but were found to have abnormal liver function by reexamination after treatment (defined as secondary group). For the primary group, the evidence of abnormal liver function was not found for 3 patients (3/13, 23.1%), and the possibility of toxic liver injury directly associated with SARS-CoV-2 infection was considered. Among the 19 patients in the secondary group, 9 (47.4%) had mild/common type and 10 (52.6%) had critical type, and all critical patients had the evidence of liver injury indirectly caused by the significant increases in C-reactive protein type, serum amyloid A, and IL-6 and hypoxemia;the evidence of abnormal liver function was not found for only 1 patient (1/19, 5.3%), and the possibility of toxic liver injury directly associated with SARS-CoV-2 infection was considered. All 32 patients with abnormal liver function had [JP2]significant reductions in liver function parameters after treatment including liver protection. Conclusion As for the patients with SARS-CoV-2 Delta variant infection who belong to the same chain of transmission in Guangdong Province, the critical patients show a significantly higher proportion of patients with abnormal liver function than the patients with other clinical types, and other factors except SARS-CoV-2 infection and indirect injury caused by SARS-CoV-2 infection are the main cause of liver injury.Copyright © 2022 Editorial Board of Jilin University. All rights reserved.

The Impact of COVID-19 Routine Life - A Survey

The COVID-19 pandemic, caused by the novel coronavirus, has had a significant impact on daily life, education, business, and trade. The virus spreads quickly through direct contact with droplets, fecal-oral transmission, and water contamination. The consequences of the pandemic can be classified into three categories: health, economic, and social. The physical, mental, and psychological behaviors of individuals have also changed due to the pandemic. This study aimed to assess the impact of COVID-19 on the general population. A survey questionnaire with ten questions was distributed through an online portal, and the responses were analyzed using SPSS software. The results showed that healthcare workers were among the most affected, with the primary impact on their social and psychological well-being. Although previous research suggested that all fields were equally affected, this study found that healthcare workers were the most impacted group. The study concluded that the COVID-19 pandemic had a significant impact on the social and psychological well-being of the general population, with healthcare workers being the most affected. © 2023 IEEE.

Efficiency of Levilimab in patients with moderate and severe COVID-19.

Objective: evaluation of the clinical and economic efficiency of using Levilimab in the treatment of moderate and severe COVID-19 based on real world data (RWD). Material and methods. A single-center observational retrospective case-control study was performed. According to the matching algorithm, 834 pairs of patients with moderate and 347 pairs with severe infection were selected, similar in gender, age, vaccination status, severity of the disease and the level of C-reactive protein. Results. The clinical efficiency of Levilimab with respect to in-hospital mortality was demonstrated both for the moderate course (6% in the Levilimab group and 10% in the standard therapy group;odds ratio (OR) 1.71;95% confidence interval (CI) 1.19-2.47;p<0.01) and for the severe course of COVID-19 (63% and 82%, respectively;OR 2.70;95% CI 1.90-3.82;p<0.01). The costs per 1 treated patient were also higher in the Levilimab therapy groups: the difference in costs compared to the standard therapy group for patients with moderate disease was 54 665.30 rubles, with severe disease - 91 285.85 rubles. The estimated cost of the additional effectiveness of Levilimab for the moderate course of the disease was 13, 666.32 rubles, for the severe course - 4, 804.51 rubles. Conclusion. The use of Levilimab for the treatment of moderate and severe COVID-19 is feasible both from a clinical and economic points of view. Conducting RWD trials is an important tool to understand the effectiveness of medical technologies in real clinical practice.Copyright © 2023 IRBIS LLC. All Rights Reserved.

Evaluation of the Effectiveness of Remdesivir in the Treatment of COVID-19 Outpatients: A Retrospective Cohort Study

Background: The outbreak of acute respiratory syndrome with novel coronavirus 2019 (COVID-19) in December 2019 in Wuhan, China, caused a worldwide outbreak of the disease. To treat the disease, some drugs were identified and introduced that did not show a significant effect on the recovery of the disease. Due to the need to manage inpatient beds, this study was conducted to evaluate the effectiveness of Remdesivir in the treatment of outpatients with moderate to severe COVID-19. Method(s): The present study was a retrospective cohort with a convenience sampling method. It was conducted by referring to the records of COVID-19 patients who were referred to the respiratory clinic of Shahid Beheshti Hospital as outpatients in the period from April to August 2021. Result(s): This study was conducted on 263 COVID-19 patients with a mean age of 51.16+/-14.39 years from 19 and 90 years old. Data were collected through a researcher-made checklist and analyzed using SPSS 20. Kolmogorov-Smirnov test, paired t-test, and Mc Nemar's test were used to evaluate the data. The significance level was considered at the level of 0.05. Conclusion(s): Findings revealed that no clear correlation was found between hospitalization and death rate compared to other patients. In our study, the risk factors for severe COVID-19 did not affect the rate of hospitalization or death of patients.Copyright © 2023 Bentham Science Publishers.

PROTOCOLS FOR RESTARTING TOURISM IN COVID-19 CONDITIONS AND DEVELOPING PANDEMIC IMMUNITY.

The purpose of the study is to provide a better understanding of the protocols for restarting tourism considered as an international prior action plan, and to present an academic output supporting the development of pandemic immunity. In this direction, the global guidelines of United Nations World Tourism Organization dated 28 May 2020 and new-normal protocols of World Travel and Tourism Council dated 29 May 2020 were translated into Turkish and subjected to content analysis. The entire analysis process, from coding to Sankey diagram creation, conducted via ATLAS.ti - v.22.1.4.0, a computer-aided qualitative data analysis software. Among the results;the role in restarting tourism and the aspects of developing pandemic immunity of implementing hygiene-oriented innovative practices even if they will require changes in the organizational chart, prioritizing coordination, communication and cooperation not only in the steps taken by the government and businesses but also by the other interested parties, making the dynamism within the internal processes brought about by the turbulent conditions efficient and standardized via the adoption of protocols establishing a specific business manner and procedure are stand out. (English) [ FROM AUTHOR] Çalışmanın amacı;uluslararası nitelikteki turizmi yeniden başlatma protokollerinin detaylı bir şekilde incelenerek somutlaştırılmasıdır. Böylece benzer krizlerin şok etkisini kısaltan, eyleme geçme sürecini daha etkili ve hızlı kılan bir pandemi bağışıklığının geliştirilmesine katkı sağlanması hedeflenmektedir. Bu doğrultuda, Türkçeye çevrilmiş olan Birleşmiş Milletler Dünya Turizm Örgütü'nün 28 Mayıs 2020 tarihli küresel yönergesi ile Dünya Seyahat ve Turizm Konseyi'nin 29 Mayıs 2020 tarihli yeni-normal protokolleri içerik analizine tabi tutulmuştur. Kodlama işleminden Sankey diyagramı oluşturmaya kadar tüm analiz süreci, bilgisayar destekli bir nitel veri analiz yazılımı olan ATLAS.ti - v.22.1.4.0 vasıtasıyla gerçekleştirilmiştir. Sonuçlar arasından;örgüt şemasında değişimleri gerektirecek olsa dahi hijyen odaklı inovatif uygulamaların hayata geçirilmesinin, yalnızca hükümetin ve işletmelerin değil;diğer ilgili tarafların atacağı adımlarda da koordinasyonun, iletişimin ve iş birliğinin öncelikli olarak değerlendirilmesinin, çalkantılı koşulların işletme içi süreçlerde meydana getirdiği olumsuzlukların protokollerin benimsenmesi aracılığıyla standardize edilmesinin ve verimli kılınmasının, turizmin yeniden başlatılmasındaki rolü ve pandemi bağışıklığını geliştirici yönleri ön plana çıkmaktadır. (Turkish) [ FROM AUTHOR] Copyright of Pamukkale University Journal of Social Sciences Institute / Pamukkale Üniversitesi Sosyal Bilimler Enstitüsü Dergisi is the property of Pamukkale University, Social Sciences Institute and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)

Fragmented Transparency: The Visibility of Agency Science in European Union Risk Regulation

Responding to mistrust in the European agencies' risk assessments in politically salient cases, the European Union (EU) legislator, the European Food Safety Authority and the European Medicines Agency alike have accelerated their efforts to foster EU regulatory science transparency. These simultaneous endeavours have, however, taken place in a fragmented legislative and administrative context, with each agency operating under a different legal framework. By focusing on authorisation procedures, from registration of studies to authorisation of novel foods, pesticides and human medicines, this article examines the resulting regimes governing the disclosure of scientific data by EU agencies to identify common trends and sectoral specificities. Against the background of an overall shift towards enhanced transparency, we shed light on, first, the circulation of institutional arrangements and practices among agencies and, second, the new dimensions of transparency emerging from these developments. We also highlight the remaining sectoral differences and argue that they could have potentially large impacts on the amount and type of information disclosed and on the level of transparency perceived by stakeholders and citizens. We argue that more coherence across the sectoral transparency regimes is needed, in particular in light of the agencies' contested legitimacy and of their increasing cooperation on cross-cutting issues like antimicrobial resistance and medicine and pesticide residues in food.

Cough Detection for Prevention Against the COVID-19 Pandemic

This paper proposes a novel and robust technique for remote cough recognition for COVID-19 detection. This technique is based on sound and image analysis. The objective is to create a real-time system combining artificial intelligence (AI) algorithms, embedded systems, and network of sensors to detect COVID-19-specific cough and identify the person who coughed. Remote acquisition and analysis of sounds and images allow the system to perform both detection and classification of the detected cough using AI algorithms and image processing to identify the coughing person. This will give the ability to distinguish between a normal person and a person carrying the COVID-19 virus. © 2023, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

COVID-related incentive payments to healthcare workers

Introduction/Objective The study estimates the associations between the key pandemic indicators and the allocation of COVID-19-related bonus and welfare payments to Russian healthcare workers. Methods The study uses regression analysis. Results The study examines two consecutive types of COVID-19-related bonus payments: (1) incentive payments (in 2020) and (2) welfare payments (in 2020–2022). Concerning incentive payments (type 1), the study supports hypotheses regarding the association between the number of persons infected with COVID-19 in a relevant region and the actual/estimated amount of budget transfers to a relevant region for bonus payments to medical workers (a) for special working conditions and additional workload and (b) for performing particularly important work. As for welfare payments (type 2), the study supports hypotheses regarding the association between (1) COVID-19 cases, (2) COVID-19 recoveries, and (3) the fiscal year-end closeout and the amount of welfare payments. Conclusion The main channel for financing payments to medical workers is a special welfare payment through the system of the Social Insurance Fund of the Russian Federation. This source exceeds the estimated total transfers and subsidies for similar purposes in 2020. The study tests hypotheses regarding the association between the key pandemic indicators and the size of various types of budget transfers for bonus and welfare payments to medical workers. © 2023, Serbia Medical Society. All rights reserved.

Frontiers of COVID-19: Scientific and Clinical Aspects of the Novel Coronavirus 2019

This book aims to serve the critical interests of the global community by supplying the most current knowledge and understanding of Covid-19 epidemiology, treatment, and prognoses. There was much uncertain and contradictory information published in the first year of the novel coronavirus. The dynamics of COVID-19 have now been realized, including the type of antibodies produced in infected patients and their limited lasting endurance. This book will set the record straight on the concept of "herd immunity” and explore the current vaccine trials taking place in different countries. This comprehensive book will illuminate recent advances regarding COVID-19 and offer a possible roadmap on how to move forward. Frontiers of COVID-19: A Pathophysiology and Epidemiology Roadmap of Novel Coronavirus Disease will be a vital and forward-looking guide for infectious disease clinicians, scientists and researchers, and students at the graduate level. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.

Covid-19 imaging: A narrative review.

BACKGROUND: The 2019 novel coronavirus disease (COVID-19) imaging data is dispersed in numerous publications. A cohesive literature review is to be assembled. OBJECTIVE: To summarize the existing literature on Covid-19 pneumonia imaging including precautionary measures for radiology departments, Chest CT's role in diagnosis and management, imaging findings of Covid-19 patients including children and pregnant women, artificial intelligence applications and practical recommendations. METHODS: A systematic literature search of PubMed/med line electronic databases. RESULTS: The radiology department's staff is on the front line of the novel coronavirus outbreak. Strict adherence to precautionary measures is the main defense against infection's spread. Although nucleic acid testing is Covid-19's pneumonia diagnosis gold standard; kits shortage and low sensitivity led to the implementation of the highly sensitive chest computed tomography amidst initial diagnostic tools. Initial Covid-19 CT features comprise bilateral, peripheral or posterior, multilobar ground-glass opacities, predominantly in the lower lobes. Consolidations superimposed on ground-glass opacifications are found in few cases, preponderantly in the elderly. In later disease stages, GGO transformation into multifocal consolidations, thickened interlobular and intralobular lines, crazy paving, traction bronchiectasis, pleural thickening, and subpleural bands are reported. Standardized CT reporting is recommended to guide radiologists. While lung ultrasound, pulmonary MRI, and PET CT are not Covid-19 pneumonia's first-line investigative diagnostic modalities, their characteristic findings and clinical value are outlined. Artificial intelligence's role in strengthening available imaging tools is discussed. CONCLUSION: This review offers an exhaustive analysis of the current literature on imaging role and findings in COVID-19 pneumonia.

[Morphological aspects of diaphragm dysfunction in COVID-19-associated pneumonia]. / Morfologicheskie aspekty disfunktsii diafragmy pri COVID-19-assotsiirovannoi pnevmonii.

OBJECTIVE: To assess morphological changes in the diaphragm and phrenic nerve in patients who died from COVID-19. MATERIAL AND METHODS: In a case-control study, an analysis was made of autopsy material of the diaphragm and phrenic nerve of those who died from COVID-19 infection complicated by SARS-CoV-2-associated pneumonia, confirmed in vivo by the presence of SARS-CoV-2 RNA (Group 1, n=12), and those who died with a diagnosis of acute cerebrovascular accident of the ischemic type without parenchymal respiratory failure (Group 2, n=3). RESULTS: The main histopathological features in the diaphragm of the 1st group were the edema of the pericellular spaces of muscle fibers, edema of perivascular spaces, diapedese hemorrhages, plethora in arteriolas, in most veins and capillaries, red blood clots were revealed; in the diaphragmatic nerve - swelling of the perineral space, severe edema around the nerve fibers inside the nerve trunk. In the diaphragm of group 2, edema of pericellular spaces of muscle fibers and edema of perivascular spaces were less pronounced (p<0.001), hemorrhages were not determined; in the diaphragmatic nerve, moderate edema of the perineral space, mild swelling inside the nerve trunk around the nerve fibers was revealed (p<0.001). The glycogen content in the muscle cells of group 1 is significantly lower compared to group 2 (p<0.001). CONCLUSION: The study confirms the characteristic pathological picture of organ damage in COVID-19. However, the leading pathological mechanism of organ damage requires further investigation.